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实验室

10:30-11:30, Thursday, July 4, 2019


Speaker: Lingjuan Zhang, Ph.D.

Professor,

School of Pharmaceutical Sciences,

Xiamen University

Topic: Multiple functions of Antimicrobial peptides in the Coordinated, Layered innate Defense System of the Skin

Host:  Ting Chen, Ph.D.

Abstract

The skin, the largest organ of our body, provides several layers of physical and immunologically active barriers against pathogens and environmental insults. Dysfunction of skin barrier can cause severe infections as well as the development of inflammatory diseases, such as psoriasis, atopic dermatitis, systemic lupus erythematosus, fibrotic skin diseases, asthma and allergic rhinitis. During the past few years, my research has been focused on understanding the innate immune defense function of major skin resident cells, including epidermal keratinocytes, fibroblasts, preadipocytes and adipocytes. We have found that antimicrobial peptide cathelicidin drives skin inflammation upon skin injury and during psoriasis pathogenesis by enabling the dsRNA-MAVS-IFNβ innate immune signaling cascade in epidermal keratinocytes (2016,Immunity). We have also discovered the previous unknown innate immune antimicrobial function of dermal white adipose (dWAT), the deepest and last barrier of the skin. We have found that dermal adipocytes play a critical role in skin defense against invasive S. aureus infection by producing antimicrobial peptides (2015, Science). Recently, we have reported that this beneficial antimicrobial function of dWAT is lost during aging by an age-dependent activation of the TGFBR pathway, which drives a pro-adipogenic to pro-fibrotic switch of dermal fibroblasts, leading to a loss of antimicrobial function of dermal fat with advancing age (Immunity,2019). Together, our research findings have advanced current understanding of the innate immune responses of skin resident cells during host defense as well as disease pathogenesis, and we have demonstrated that proper innate immune activation of these cells is critical for the maintenance of the coordinated, layered innate defense system of the skin.